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Related Experiment Videos

Chemotherapy for pilocytic astrocytomas

M T Brown1, H S Friedman, W J Oakes

  • 1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.

Cancer
|May 15, 1993
PubMed
Summary

Chemotherapy shows promise for progressive pilocytic astrocytomas (PA) in children, offering clinical and radiographic improvement in 36% of patients. It may also delay radiation therapy for unresectable PA, indicating PA

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Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Clinical Pharmacology

Background:

  • Pilocytic astrocytomas (PA) are typically benign brain tumors.
  • A subset of PA patients experience disease progression despite standard surgery and radiation therapy.
  • Chemotherapy is explored as a treatment option for progressive or unresectable PA.

Purpose of the Study:

  • To evaluate the efficacy and safety of chemotherapy in pediatric patients with progressive pilocytic astrocytomas.
  • To assess chemotherapy's role in delaying radiation therapy for young children with unresectable PA.

Main Methods:

  • Eleven pediatric patients with pathologically confirmed PA received chemotherapy.
  • Treatment regimens varied, with ten different protocols used across the cohort.

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  • Chemotherapy was administered post-progression after surgery/radiation or as an alternative to radiation in young children.

    • Main Results:

    • Overall, 36% of patients achieved clinical and radiographic response (R/R).
    • An additional 9% showed stabilization with radiographic improvement (SD/R), and 27% had stable disease (SD/SD).
    • Hematologic toxicities required dose reductions in 39% of courses; one chemotherapy-related death occurred.

    Conclusions:

    • Chemotherapy may benefit patients with progressive, inoperable pilocytic astrocytomas.
    • It can potentially delay the need for radiation therapy in young patients with unresectable PA.
    • Pilocytic astrocytoma demonstrates chemosensitivity as a primary brain tumor.