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Polymyositis associated with ulcerative colitis

S Chugh1, J B Dilawari, I M Sawhney

  • 1Department of Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Gut
|April 1, 1993
PubMed
Summary
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A woman with chronic ulcerative colitis experienced polymyositis symptoms. Treatment resolved both conditions, suggesting an autoimmune link between ulcerative colitis and polymyositis.

Area of Science:

  • Gastroenterology
  • Neurology
  • Rheumatology

Background:

  • Chronic ulcerative colitis is an inflammatory bowel disease.
  • Polymyositis is an idiopathic inflammatory myopathy characterized by muscle weakness.

Observation:

  • An elderly female patient presented with symptoms of polymyositis, including proximal muscle weakness, elevated creatine phosphokinase, and characteristic electromyographic and histological findings.
  • These symptoms occurred in the context of pre-existing chronic ulcerative colitis.

Findings:

  • Treatment with corticosteroids and 5-acetylsalicylic acid led to remission of ulcerative colitis symptoms.
  • The patient also showed improvement in muscle strength and reversal of electromyographic abnormalities.
  • Serum creatine phosphokinase levels normalized.

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Implications:

  • The case suggests a potential autoimmune connection between chronic ulcerative colitis and polymyositis.
  • This highlights the importance of considering associated autoimmune conditions in patients with inflammatory bowel disease.
  • Further research into shared autoimmune mechanisms may be warranted.