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Measles associated hepatobiliary disease: an overview
R Khatib1, M Siddique, M Abbass
1St. John Hospital and Medical Center, Detroit, Michigan 48236.
Infection
|March 1, 1993
Summary
This review of measles cases with liver disease identified two patterns: early hepatocellular dysfunction and later cholestasis. Measles-associated hepatitis often presents asymptomatically with aminotransferase elevation.
Area of Science:
- Hepatology
- Infectious Diseases
- Virology
Background:
- Measles is a highly contagious viral illness.
- Hepatobiliary complications are rare but can occur.
- Understanding these complications is crucial for patient management.
Purpose of the Study:
- To review and characterize documented cases of measles-associated hepatitis.
- To describe the clinical and laboratory presentations of liver disease in measles patients.
Main Methods:
- Literature review of all documented cases of measles with hepatobiliary disease.
- Analysis of patient demographics, clinical presentation, and laboratory findings.
Main Results:
- 27 patients with measles-associated hepatitis were identified.
- Two distinct patterns of liver injury were observed: hepatocellular dysfunction (24/27 cases) and cholestasis (3/27 cases).
- Hepatocellular dysfunction was typically early, asymptomatic, and transient, while cholestasis appeared later and was more prolonged.
Conclusions:
- Measles can cause distinct patterns of hepatitis, suggesting different pathogenetic mechanisms.
- Hepatocellular dysfunction is the more common presentation, often resolving quickly.
- Cholestatic hepatitis is less common but more persistent.