Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

3D MPRAGE evaluation of the internal auditory canals

M Shah1, J S Ross, J Tkach

  • 1Division of Radiology, Cleveland Clinic Foundation, OH 44195.

Journal of Computer Assisted Tomography
|May 1, 1993
PubMed
Summary

Magnetization Prepared Rapid Acquisition Gradient Echo (MPRAGE) offers detailed T1-weighted imaging for internal auditory canal abnormalities. This 3D sequence is a valuable adjunct to conventional MRI, providing excellent gray-white differentiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship of tumor fraction in circulating tumor DNA with prognosis in patients with advanced urothelial cancer.

ESMO real world data and digital oncology·2026
Same author

Mutational patterns and ancestry-linked profiles in a large hepatocellular carcinoma and combined hepatocellular-cholangiocarcinoma cohort.

ESMO open·2026
Same author

Impact of increased smoothing by spectral dispersion bandwidth on stimulated Brillouin scattering in laser driven Hohlraums.

Optics express·2025
Same author

Identifying the genomic landscape of EGFR-mutant lung cancers with central nervous system metastases.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Squamous cell carcinoma of unknown primary (SCCUP): a genomic landscape study.

ESMO open·2025
Same author

Direct Evidence of Multispecies Hydrodynamics in Ignition-Scale Hohlraums.

Physical review letters·2025

Area of Science:

  • Radiology
  • Medical Imaging

Background:

  • Magnetization Prepared Rapid Acquisition Gradient Echo (MPRAGE) is a 3D gradient echo sequence.
  • It utilizes a 180-degree inversion pulse for heavily T1-weighted imaging.
  • MPRAGE provides excellent anatomic detail and signal-to-noise ratio with optimized parameters.

Purpose of the Study:

  • To evaluate the clinical utility of 3D MPRAGE for detecting internal auditory canal abnormalities.
  • To compare MPRAGE performance against conventional spin echo (SE) imaging.
  • To assess MPRAGE's potential as an adjunct or replacement for specific MRI sequences.

Main Methods:

  • A 3D MPRAGE sequence was used with specific parameters: 128 coronal partitions, 10-degree flip angle, 130x256 matrix, 2mm slice thickness, 350ms inversion time, and 1s recovery time.

Related Experiment Videos

  • Thirty patients (15 men, 15 women) with various diagnoses were evaluated.
  • Conventional SE T1-weighted imaging was used as a comparison.

    • Main Results:

    • All enhancing lesions identified on conventional SE imaging were also detected by MPRAGE.
    • No diagnostic differences were found between MPRAGE and SE when pathology was present.
    • MPRAGE exhibited poorer resolution in axial reformats compared to SE due to the in-plane matrix.

    Conclusions:

    • 3D MPRAGE is a valuable adjunct for routine MRI protocols, particularly for internal auditory canal imaging.
    • It demonstrates excellent gray-white matter differentiation and provides contiguous thin sections.
    • While not a complete replacement for conventional SE, MPRAGE can potentially replace coronal T1-weighted SE sequences.