Related Experiment Videos
[Expression of activation antigen CD69 on eosinophils]
1Second Department of Internal Medicine, Nara Medical University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 1, 1993
Summary
CD69 is expressed on eosinophils at inflammatory sites, but not typically in peripheral blood. This suggests CD69 can mark activated eosinophils in localized inflammation.
Area of Science:
- Immunology
- Cell Biology
Context:
- CD69 is a known marker of activated lymphocytes.
- Its role in eosinophils, particularly at inflammatory sites, was previously unclear.
Purpose:
- To investigate the expression of CD69 on eosinophils.
- To determine if CD69 expression is indicative of eosinophil activation in inflammatory conditions.
Summary:
- CD69 was significantly expressed on lung eosinophils from bronchoalveolar lavage fluid and pleural effusion.
- Peripheral blood eosinophils generally lacked CD69 expression.
- In vitro stimulation with IL-3, IL-5, GM-CSF, and PMA induced CD69 expression on peripheral blood eosinophils.
Impact:
- CD69 expression on eosinophils appears restricted to local inflammatory sites.
- CD69 may serve as a valuable biomarker for identifying activated eosinophils in inflammatory lung diseases.