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Fibrinolytic and hemostatic parameter response after resistance exercise
1Department of Sport and Environmental Science, Crewe+Alsager Faculty, Manchester Metropolitan University, Alsager, Cheshire, England.
Medicine and Science in Sports and Exercise
|May 1, 1993
Summary
Resistance exercise, including high and low volume, did not significantly alter key hemostatic and fibrinolytic system parameters in healthy subjects. Further research is needed to explore potential subtle effects.
Area of Science:
- Exercise Physiology
- Hemostasis and Fibrinolysis
Background:
- The hemostatic and fibrinolytic systems are crucial for blood clot formation and dissolution.
- Understanding how different exercise intensities affect these systems is important for health and performance.
Purpose of the Study:
- To investigate the impact of high-volume resistance exercise (HVRE) and low-volume resistance exercise (LVRE) on hemostatic and fibrinolytic parameters.
- To compare these effects against a control condition with no exercise.
Main Methods:
- Seven healthy subjects underwent three randomized trials: control, HVRE, and LVRE.
- Blood samples were analyzed for lactic acid, tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), and Factor VIII (FVIII) activity.
- Global fibrinolysis and plasma volume changes were also assessed.
Main Results:
- No significant changes were observed in measured hemostatic or fibrinolytic parameters under the control condition.
- Neither HVRE nor LVRE resulted in statistically significant alterations in the evaluated blood markers.
- Individual variations in response were noted, but overall group data showed no significant differences.
Conclusions:
- Resistance exercise, as performed in this study, does not appear to significantly impact major hemostatic and fibrinolytic markers in healthy individuals.
- The study suggests that acute resistance training may not acutely influence the balance of blood coagulation and fibrinolysis.