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Related Experiment Videos

Regular inhaled beta agonist in asthma: effects on exacerbations and lung function

D R Taylor1, M R Sears, G P Herbison

  • 1Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.

Thorax
|February 1, 1993
PubMed
Summary

Regular use of inhaled fenoterol for asthma control led to more exacerbations and worsened lung function. This study suggests chronic beta-agonist treatment may be harmful for long-term asthma management.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Clinical Medicine

Background:

  • Asthma exacerbations and lung function were previously compared between regular and as-needed inhaled beta-agonist treatments.
  • This study provides further data on asthma exacerbations, lung function trends, and airway responsiveness over 24-week treatment periods.

Purpose of the Study:

  • To evaluate the effects of regular versus as-needed inhaled beta-agonist (fenoterol) treatment on asthma control.
  • To assess trends in lung function, airway hyperresponsiveness, and bronchodilator responsiveness during the entire 24-week treatment periods.

Main Methods:

  • A year-long randomized, double-blind crossover study involving 64 asthma subjects.
  • Subjects received regular fenoterol (400 micrograms) or placebo four times daily for 24 weeks, followed by crossover.

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  • Lung function, airway responsiveness to methacholine, and bronchodilator response were measured throughout the study.

    • Main Results:

    • Regular fenoterol treatment resulted in more frequent and earlier asthma exacerbations, including severe events requiring hospitalization.
    • Significant declines in baseline lung function (FEV1 and VC) and increased diurnal variation in peak flow were observed.
    • Airway hyperresponsiveness to methacholine increased significantly, while bronchodilator responsiveness remained unaffected.

    Conclusions:

    • Chronic use of inhaled fenoterol is associated with increased asthma exacerbations and a decline in lung function.
    • The findings indicate that regular inhaled beta-agonist treatment may be detrimental to long-term asthma control.
    • Bronchodilator responsiveness was not altered, suggesting no tachyphylaxis developed.