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Related Experiment Videos

Progress in protein structure prediction?

B Rost1, R Schneider, C Sander

  • 1EMBL, Heidelberg, Germany.

Trends in Biochemical Sciences
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

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Protein structure prediction accuracy improves significantly with related protein sequences. Analyzing multiple sequence alignments reveals real progress in predicting protein secondary structures, even if some claims are exaggerated.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Protein secondary structure prediction remains a long-standing challenge in molecular biology.
  • Recent claims of success in predicting the catalytic subunit of cAMP-dependent protein kinase warrant critical assessment.

Purpose of the Study:

  • To critically evaluate the progress in protein secondary structure prediction methods.
  • To determine the impact of using related protein sequences on prediction accuracy.

Main Methods:

  • Assessment of prediction success claims using established test cases.
  • Analysis of protein structure prediction performance with and without multiple sequence alignments.

Main Results:

  • Some previously claimed successes in protein structure prediction were found to be exaggerated upon critical review.

Related Experiment Videos

  • A notable improvement in prediction accuracy was observed when utilizing a family of related protein sequences.

    • Conclusions:

    • While some claims may be overstated, there is demonstrable progress in protein secondary structure prediction.
    • The availability of multiple sequence alignments significantly enhances the accuracy of protein structure prediction, encouraging further adoption by molecular biologists.