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Method for sequential staining of GTL-banded metaphases with fluorescent-labeled chromosome-specific paint probes
S M Jalal1, M E Law, E R Christensen
1Section of Laboratory Genetics, Mayo Clinic, Rochester, Minnesota 55905.
American Journal of Medical Genetics
|April 1, 1993
Abstract:
We describe a method for use of fluorescent-labeled whole chromosome-specific paint probes on GTL-banded metaphases to utilize the combined potential of these techniques for defining chromosome abnormalities. The efficacy of this method was tested on 6 cases involving different chromosome abnormalities and various tissues, including blood, amniotic fluid, skin fibroblasts, and bone marrow.