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Related Experiment Videos

Bipolar II: the most common bipolar phenotype?

S G Simpson1, S E Folstein, D A Meyers

  • 1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.

The American Journal of Psychiatry
|June 1, 1993
PubMed
Summary

Bipolar II disorder is the most common affective disorder in families of both bipolar I and bipolar II probands. Accurate diagnosis of bipolar II disorder is crucial for understanding the genetic basis of bipolar disorders.

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Area of Science:

  • Psychiatry
  • Genetics
  • Clinical Psychology

Background:

  • Bipolar I and Bipolar II disorders are distinct mood disorders.
  • Family studies are essential for understanding the genetic underpinnings of psychiatric conditions.

Purpose of the Study:

  • To compare the prevalence and pattern of affective psychopathology in families of Bipolar I probands versus Bipolar II probands.
  • To investigate the genetic relationship between Bipolar I and Bipolar II disorders.

Main Methods:

  • Interviews using the Schedule for Affective Disorders and Schizophrenia--Lifetime Version were conducted.
  • First-degree relatives of 48 Bipolar I and 8 Bipolar II probands were assessed.
  • High interrater reliability was maintained for diagnoses.

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Main Results:

  • Bipolar II disorder was the most frequent diagnosis in both family groups.
  • 40% of Bipolar II proband relatives and 22% of Bipolar I proband relatives were diagnosed with Bipolar II disorder.
  • Bipolar I disorder was rarely observed in Bipolar II families.

Conclusions:

  • Bipolar II disorder is the most prevalent phenotype in both Bipolar I and Bipolar II families.
  • Bipolar II disorder appears genetically related to, yet less complex than, Bipolar I disorder.
  • Precise diagnosis of Bipolar II disorder is vital for identifying genetic loci associated with bipolar disorders.