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Mast cells in human ulcers

L L Bolton1, W Montagna

  • 1Johnson & Johnson Patient Care Division, Oregon Regional Primate Research Center, Beaverton.

The American Journal of Dermatopathology
|April 1, 1993
PubMed
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Mast cells are present in various skin ulcer types, particularly in granulation tissue and epidermis. Their role in ulcer healing and necrosis warrants further investigation.

Area of Science:

  • Dermatology
  • Histopathology
  • Wound Healing Research

Background:

  • Mast cells are immune cells found in connective tissues.
  • Their specific distribution and function in chronic human skin ulcers are not fully understood.
  • Previous studies have not extensively detailed mast cell presence across different ulcer etiologies.

Purpose of the Study:

  • To investigate and compare the distribution patterns of mast cells in three common types of human skin ulcers: decubitus, venous stasis, and arteriosclerotic ulcers.
  • To explore the presence of mast cells within the epidermis and granulation tissue of these ulcers.
  • To examine the morphology of mast cells and their granules in ulcerated skin.

Main Methods:

  • Histological examination of skin biopsy samples from decubitus, venous stasis, and arteriosclerotic ulcers.

Related Experiment Videos

  • Mast cell identification using specific staining techniques.
  • Quantitative and qualitative assessment of mast cell distribution in different skin layers (papillary dermis, reticular dermis, epidermis) and in granulation and necrotic tissues.

    • Main Results:

    • Mast cells were predominantly found in the papillary dermis and reticular dermis across all studied ulcer types.
    • Significant numbers of mast cells were observed within the epidermis and abundant in granulation tissue.
    • Intraepidermal mast cell counts were notably higher in venous stasis ulcers compared to decubitus and arteriosclerotic ulcers.
    • Intact mast cells, as well as free and intracellular granules, were identified in necrotic and granulation tissues.

    Conclusions:

    • Mast cells exhibit distinct distribution patterns in decubitus, venous stasis, and arteriosclerotic skin ulcers.
    • The presence of intraepidermal mast cells, especially in venous stasis ulcers, suggests a potential role in epidermal changes during ulceration.
    • The observation of mast cell granules in necrotic and granulation tissues raises questions about their involvement in ulcer necrosis and the repair process.