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Miniaturized flexible amperometric lactate probe

D L Wang1, A Heller

  • 1Department of Chemical Engineering, University of Texas, Austin 78712-1062.

Analytical Chemistry
|April 15, 1993
PubMed
Summary
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A novel flexible lactate electrode was developed using carbon fibers and modified with a poly(vinylpyridine) complex and lactate oxidase. This biosensor demonstrates stable performance and reduced interference for accurate lactate detection.

Area of Science:

  • Biomedical Engineering
  • Electrochemistry
  • Biosensors

Background:

  • Lactate detection is crucial for diagnosing various medical conditions.
  • Existing lactate sensors face challenges with stability and interference.
  • Development of robust and selective biosensors is an ongoing need.

Purpose of the Study:

  • To develop a flexible and stable electrode for lactate detection.
  • To enhance selectivity by minimizing interference from other electroactive species.
  • To characterize the performance and stability of the novel lactate biosensor.

Main Methods:

  • Fabrication of a flexible electrode using carbon fibers and polyimide tubing.
  • Modification of the electrode with a poly(vinylpyridine)-Osmium complex and lactate oxidase.

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  • Electrochemical characterization of lactate oxidation current and sensitivity.
  • Implementation of electrical insulation and enzyme-based interference reduction strategies.

    • Main Results:

    • The electrode exhibited a steady-state current of 400 nA at 2 mM lactate.
    • Sensitivity showed minimal decrease (5%) with increased oxygen partial pressure.
    • The biosensor maintained sensitivity after 4 months of dry storage at 4°C.
    • Interference from ascorbate was reduced by a factor of 20 using a horseradish peroxidase/glucose oxidase film.

    Conclusions:

    • A flexible and stable lactate biosensor was successfully developed.
    • The sensor design effectively minimizes interference, improving accuracy.
    • This biosensor shows promise for reliable in-situ lactate monitoring.