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Synthesis and DNA binding selectivity of pyrrole-amidine oligopeptides
1Menarini Richerche Sud, Pomezia Rome, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|February 1, 1993
Abstract:
A class of DNA binding antibiotics endowed with antiviral and antitumor properties is reviewed. Starting from the original natural products, namely distamycin and netropsin, new compounds have been recently synthesized with the aim to obtain agents with specific affinity for defined DNA sequences and with different interaction mechanism (reversible or irreversible).