Related Experiment Videos
Heterocyclic modulators of the NMDA receptor
R Pellicciari1, B Natalini, G Costantino
1Istituto di Chimica Farmaceutica e Tecnica Farmaceutica Universita degli Studi, Perugia, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|February 1, 1993
Abstract:
The design of new heterocyclic derivatives as modulatory agents at EAA receptors is described. In particular, the potent and selective activity at the NMDA receptor of trans-4-hydroxypipecolic acid-4-sulfate, as well as the neuroprotective properties of substituted thiokynurenates, a new class of competitive antagonists at the glycine site of the NMDA receptor complex, are reported.