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Related Experiment Videos

Ankylosing spondylitis successfully treated with methotrexate

K Yamane1, C Saito, H Natsuda

  • 1Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.

Internal Medicine (Tokyo, Japan)
|January 1, 1993
PubMed
Summary

Methotrexate (MTX) effectively treated a patient with co-occurring ankylosing spondylitis and psoriasis. This treatment improved joint symptoms, skin condition, and inflammatory markers, allowing the patient to return to work.

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Area of Science:

  • Rheumatology
  • Dermatology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
  • Psoriasis is a chronic autoimmune disease that causes skin inflammation and joint problems.
  • Co-occurrence of AS and psoriasis presents complex treatment challenges.

Observation:

  • A 37-year-old male patient presented with a history of ankylosing spondylitis diagnosed in 1980.
  • The patient developed psoriasis in 1991, experiencing significant functional impairment.
  • Conventional antirheumatic drugs provided insufficient relief for his combined conditions.

Findings:

  • Methotrexate (MTX) was initiated at 7.5 mg/week per os in May 1991.
  • Significant improvement in joint symptoms, psoriasis, and acute phase reactants was observed within one month.

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  • Sustained improvement exceeding six months was noted following MTX treatment.

    • Implications:

    • Methotrexate demonstrates efficacy in managing combined ankylosing spondylitis and psoriasis.
    • Early intervention with MTX can lead to substantial symptom relief and functional recovery.
    • This case highlights MTX as a viable therapeutic option for patients with coexisting spondyloarthritis and psoriasis.