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Acute ethanol intake produces lipid peroxidation in rat red blood cells membranes
J Gutiérrez-Salinas1, M Zentella de Piña, E Piña
1Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, D.F.
Biochemistry and Molecular Biology International
|February 1, 1993
Abstract:
The effect of acute ethanol intake on lipid peroxidation (LP) and proteins in red blood cells (RBC) was explored. The amount of malondialdehyde (MDA; an indicator of LP) was elevated transiently when the maximal ethanol level in whole blood was observed. In contrast, erythrocyte membrane proteins were not affected. In in vitro experiments both ethanol and acetaldehyde did not alter the MDA levels. These results indicate that the metabolism of ethanol or acetaldehyde beyond the RBCs is required in order to detect LP on these cells.