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Related Experiment Videos

Bronchiolitis obliterans: high resolution CT findings and correlation with pulmonary function tests

S P Padley1, B D Adler, D M Hansell

  • 1Department of Radiology, University of British Columbia, Vancouver, Canada.

Clinical Radiology
|April 1, 1993
PubMed
Summary

High-resolution CT (HRCT) reveals abnormalities in most bronchiolitis obliterans cases, but the extent of these HRCT findings does not strongly correlate with lung function impairment.

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Area of Science:

  • Radiology
  • Pulmonology
  • Thoracic Imaging

Background:

  • Bronchiolitis obliterans is a rare, irreversible obstructive lung disease.
  • High-resolution CT (HRCT) is a key imaging modality for evaluating lung parenchyma and airways.
  • Understanding the relationship between HRCT findings and pulmonary function is crucial for patient management.

Purpose of the Study:

  • To characterize the HRCT appearances of bronchiolitis obliterans.
  • To correlate the extent of HRCT abnormalities with pulmonary function test results.

Main Methods:

  • Retrospective analysis of HRCT scans from 18 patients diagnosed with bronchiolitis obliterans.
  • Two independent radiologists assessed HRCT findings.
  • Correlation analysis between HRCT abnormality extent and pulmonary function parameters (static lung volumes, gas transfer, FEV1).

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Main Results:

  • All patients exhibited abnormal HRCT findings.
  • Common abnormalities included decreased parenchymal attenuation, bronchial dilatation (subsegmental and segmental), and centrilobular branching structures.
  • No significant correlation was found between the overall extent of HRCT abnormalities and static lung volumes or gas transfer impairment.
  • A significant positive correlation was observed between subsegmental bronchial dilatation and forced expiratory volume in one second (FEV1).

Conclusions:

  • HRCT is sensitive in detecting abnormalities in bronchiolitis obliterans.
  • The extent of HRCT abnormalities shows a weak correlation with overall lung function impairment.
  • Subsegmental bronchial dilatation on HRCT may serve as a specific indicator related to FEV1 in bronchiolitis obliterans.