Paralytic syndrome attributed to lasalocid residues in a commercial ration fed to dogs

Lasalocid, accidently introduced into a commercial dog food, was found to be the cause of neuromuscular toxicosis in 10 dogs. Toxicosis was confirmed in 4 principal dogs. The history, clinical signs, and pattern of onset of lasalocid-induced toxicosis in the 14 dogs were similar to those reported for botulism. The signs, which were related to a generalized lower motor neuron deficit, were generally different from ionophore-induced toxicosis reported in other species. Supportive therapy and close monitoring were sufficient to bring about a gradual improvement in all of the dogs, despite the severity of clinical signs.