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Related Experiment Videos

Progression of interdigital infections from simplex to complex

J J Leyden1

  • 1Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.

Journal of the American Academy of Dermatology
|May 1, 1993
PubMed
Summary
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Symptomatic toe web infections involve fungi and bacteria interacting. Fungal infections damage skin, allowing bacterial overgrowth, leading to complex infections that can be hard to diagnose.

Area of Science:

  • Dermatology
  • Mycology
  • Bacteriology

Background:

  • Toe web infections often result from a combination of fungal and bacterial elements.
  • Mild fungal infections (dermatophytosis simplex) can worsen in the moist toe web environment.
  • Bacterial colonization frequently follows fungal damage to the skin's stratum corneum.

Purpose of the Study:

  • To elucidate the ecological interplay between fungi and bacteria in symptomatic toe web infections.
  • To understand the progression from simple fungal infections to complex, superinfected states.
  • To highlight diagnostic challenges posed by bacterial superinfections masking fungal causes.

Main Methods:

  • Review of existing studies on toe web infections.
  • Analysis of the pathogenic mechanisms involved in fungal and bacterial co-infections.

Related Experiment Videos

  • Examination of factors influencing bacterial resistance and diagnostic difficulties.

    • Main Results:

    • Fungal infections create a niche for bacterial overgrowth, leading to maceration, itching, and odor (dermatophytosis complex).
    • Superinfecting bacteria are often resistant to common antibiotics like penicillin due to fungal metabolites.
    • Bacterial overgrowth can obscure the primary fungal infection, complicating fungal culture attempts.

    Conclusions:

    • The interaction between dermatophytes and bacteria is crucial in the pathogenesis of symptomatic toe web infections.
    • Effective treatment requires addressing both fungal and bacterial components.
    • Diagnostic strategies must account for the potential masking effect of bacterial superinfections on fungal elements.