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Atopic dermatitis: a genetic-epidemiologic study in a population-based twin sample

F Schultz Larsen1

  • 1Skin Clinic, Fredericia, Denmark.

Journal of the American Academy of Dermatology
|May 1, 1993
PubMed
Summary

The incidence of atopic dermatitis is increasing, with higher concordance rates in identical twins, suggesting a strong genetic influence. Environmental factors also play a role in genetically susceptible individuals.

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Area of Science:

  • Dermatology
  • Genetics
  • Epidemiology

Background:

  • Atopic dermatitis is a prevalent, multifactorial skin condition with increasing incidence.
  • Understanding the genetic and environmental contributions to atopic dermatitis is crucial.

Purpose of the Study:

  • To assess the incidence of atopic dermatitis.
  • To evaluate and expand upon twin concordance rates for atopic dermatitis.

Main Methods:

  • A mailed questionnaire study involving 812 twin pairs in Fyn County, Denmark.
  • Twin zygosity determined by the similarity method for cohorts born 1965-1979.

Main Results:

  • A 92% response rate was achieved.
  • Cumulative incidence of atopic dermatitis (up to 7 years) rose from 0.06 to 0.12 between 1965-1969 and 1975-1979 cohorts.

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  • Pairwise concordance rates were 0.72 for monozygotic and 0.23 for dizygotic twins.

    • Conclusions:

    • Atopic dermatitis incidence continues to rise, though at a slower pace than in previous decades.
    • High concordance rates in monozygotic twins highlight the decisive role of genetic factors.
    • Environmental factors likely interact with genetic predisposition in atopic dermatitis development.