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Related Experiment Videos

Global T wave inversion: long-term follow-up

L A Walder1, D H Spodick

  • 1Division of Cardiology, St. Vincent Hospital, Worcester, Massachusetts 01604.

Journal of the American College of Cardiology
|June 1, 1993
PubMed
Summary

Global T wave inversion shows a persistent female predominance. While diffuse ECG changes are not indicative of poor prognosis, long-term survival is negatively impacted by conditions like atrial fibrillation and malignant diseases.

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Area of Science:

  • Cardiology
  • Electrocardiography
  • Clinical Prognostics

Background:

  • Global T wave inversion presents with a long QT interval and a significant female predominance.
  • Despite dramatic electrocardiographic (ECG) changes, in-hospital prognosis is comparable to the general hospital population.

Purpose of the Study:

  • To evaluate the 11-year follow-up data of patients diagnosed with global T wave inversion.
  • To assess the long-term prognostic factors influencing survival in this patient cohort.

Main Methods:

  • Prospective follow-up of 118 patients (92 women, 26 men) with global T wave inversion for up to 11 years.
  • Analysis of in-hospital death rates and long-term survival data, comparing outcomes based on specific clinical factors.

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Main Results:

  • Long-term survival is significantly reduced in patients with malignant conditions, atrial fibrillation, faster heart rates, and those treated with digoxin.
  • A malignant condition was associated with a high mortality rate (78.3%) and a mean survival of only 12 months.
  • Digoxin use (63.9% mortality) and atrial fibrillation (58.3% mortality, often in conjunction with digoxin) indicated a poorer prognosis.

Conclusions:

  • Global T wave inversion continues to exhibit an unexplained female preponderance (78% vs. 22%).
  • The long-term prognosis is primarily determined by the presence of underlying or associated diseases, not the ECG changes themselves.
  • Diffuse ECG abnormalities in global T wave inversion do not inherently signify a poor long-term outlook.