Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The spectrum of human tuberculosis

L Lenzini, P Rottoli, L Rottoli

    Clinical and Experimental Immunology
    |February 1, 1977
    PubMed
    Summary

    This study demonstrates a spectrum of immune responses in human tuberculosis. Patients range from highly reactive with strong cell-mediated immunity to unreactive with high antibody production.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Meta-Analysis to Unveil the Diagnostic Gaps in Anderson-Fabry Disease in Women.

    Journal of inherited metabolic disease·2026
    Same author

    The effect of different structural decoration geometries on vibration propagation in spider orb webs.

    PloS one·2025
    Same author

    Status of QCD precision predictions for Drell-Yan rapidity distributions.

    The European physical journal. C, Particles and fields·2025
    Same author

    Primary Aldosteronism and Drug Resistant Hypertension: A "Chicken-Egg" Story.

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2023
    Same author

    A novel <i>MRPS34</i> gene mutation with combined OXPHOS deficiency in an adult patient with Leigh syndrome.

    Molecular genetics and metabolism reports·2021
    Same author

    SARS CoV2 infection in a young subject affected by arginosuccinate synthase deficiency: A case report of epilepsy worsening.

    Molecular genetics and metabolism reports·2020

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Human tuberculosis presents a complex clinical spectrum.
    • Understanding immune responses is crucial for disease management.
    • Previous studies suggested a range of immune reactions in tuberculosis patients.

    Purpose of the Study:

    • To investigate and define the spectrum of cell-mediated and humoral immune responses in human tuberculosis.
    • To classify patients based on their immunological profiles.
    • To provide evidence for a spectrum of immune responses in tuberculosis.

    Main Methods:

    • Assessed cell-mediated immunity using skin tests and leucocyte migration inhibition to purified protein derivative (PPD).
    • Evaluated humoral immune responses through immunodiffusion and haemagglutination tests.
    • Classified patients into reactive (RR) and unreactive (UU) groups based on immune markers.

    Main Results:

    • Identified two polar groups: reactive (RR) with strong cell-mediated immunity and low antibody levels, and unreactive (UU) with poor cellular response and high antibody production.
    • Observed intermediate patient groups exhibiting characteristics of the polar extremes.
    • Demonstrated a clear correlation between clinical presentation and immune response patterns.

    Conclusions:

    • The study confirms a spectrum of immune responses in human tuberculosis, ranging from predominantly cell-mediated to predominantly humoral.
    • Patient classification into reactive and unreactive groups provides a framework for understanding disease variability.
    • These findings highlight the importance of immunological status in tuberculosis pathogenesis and potential therapeutic strategies.

    Related Experiment Videos