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[Chronic blepharoconjunctivitis during a treatment with acitretin (Soriatane)]
P Denis1, J P Nordmann, P Saiag
1Service d'Ophtalmologie, Hôpital Saint-Antoine, Paris.
Journal Francais D'Ophtalmologie
|January 1, 1993
Summary
Acitretin, a vitamin A derivative, can cause chronic blepharoconjunctivitis in psoriasis patients. This eye condition involves dry eyes and meibomian gland issues, recurring with acitretin therapy.
Area of Science:
- Dermatology
- Ophthalmology
- Pharmacology
Background:
- Acitretin is a synthetic vitamin A analogue used for psoriasis treatment.
- Retinoids, including acitretin, are known for potential side effects.
Observation:
- A patient undergoing acitretin therapy for psoriasis developed chronic blepharoconjunctivitis.
- Ocular examination revealed epithelial defects and reduced tear break-up time.
- Meibomian gland atrophy was observed in the affected patient.
Findings:
- Conjunctival cytology and biopsy showed characteristic changes, including keratinized epithelial cells.
- Histological examination of accessory salivary glands was non-specific.
- A direct correlation was noted between acitretin therapy resumption and symptom recurrence.
Implications:
- Acitretin can induce or worsen blepharoconjunctivitis in patients with psoriasis.
- Ophthalmologists should monitor for ocular side effects in patients using acitretin.
- Understanding retinoid-induced ocular toxicity is crucial for patient management.