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Oxacillin- and quinolone-resistant Staphylococcus aureus in Sao Paulo, Brazil: a multicenter molecular epidemiology
H S Sader1, A C Pignatari, R J Hollis
1Disciplina de Doencas Infecciosas e Parasitarias, Escola Paulista de Medicina, Sao Paulo, Brazil.
Objective:
To investigate the possibility of interhospital spread of multiresistant Staphylococcus aureus in Sao Paulo, Brazil.
Design:
We evaluated 13 nosocomial S aureus strains selected because of resistance to oxacillin and ciprofloxacin.
Setting:
The strains were collected between March 1991 and September 1991 from four different hospitals in Sao Paulo. Two were teaching hospitals, and two were private hospitals.
Patients:
Each strain was isolated from a different patient. All patients were hospitalized when the strains were isolated.
Interventions:
The strains were typed by restriction endonuclease analyses of plasmid DNA (REAP) using EcoRI, HindIII, RsaI, and AluI and by extended antibiogram profile (34 drugs).
Results:
All strains had identical plasmid and antibiogram profile. They demonstrated the same plasmid pattern as previously described in one of the hospitals studied.
Conclusions:
Our results suggest the dissemination of a unique oxacillin- and quinolone-resistant strain of S aureus in several hospitals of Sao Paulo, Brazil.