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Inhaled corticosteroids--effect on bone?

M J Ward1

  • 1Asthma Education Unit, King's Mill Hospital, Sutton-in-Ashfield, Nottinghamshire, U.K.

Respiratory Medicine
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

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Long-term oral corticosteroid use, like prednisolone, increases vertebral fracture risk in asthma patients. Bone density loss is linked to the medication, not the disease itself.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Bone Metabolism

Background:

  • Asthma patients on long-term oral prednisolone show increased vertebral fractures.
  • Bone density measurements indicate corticosteroids, not asthma, cause bone loss.

Purpose of the Study:

  • To investigate the impact of oral and inhaled corticosteroids on bone density and metabolism.

Main Methods:

  • Bone density measurements in patients on oral corticosteroids.
  • Assessment of bone metabolism in normal subjects using inhaled corticosteroids.

Main Results:

  • Diminished bone density is associated with oral corticosteroid administration.
  • Inhaled corticosteroids (over 1.0 mg/day) affect bone metabolism in healthy individuals.

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Conclusions:

  • Oral corticosteroids significantly impact bone health, leading to increased fracture risk.
  • Even inhaled corticosteroids at higher doses can influence bone metabolism.