Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypertensive crisis]

V A Briner1

  • 1Medizinische Universitätsklinik, Inselspital Bern.

Schweizerische Medizinische Wochenschrift
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Hypertensive crisis requires immediate treatment to prevent organ damage from acute high blood pressure. Sodium nitroprusside is often used, but careful monitoring is needed due to potential side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Superoxide potently induces ceramide formation in glomerular endothelial cells.

Biochemical and biophysical research communications·2001
Same author

Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: effects on proapoptotic pathways.

British journal of pharmacology·2000
Same author

Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment.

Lancet (London, England)·2000
Same author

Glucocorticoids potently block tumour necrosis factor-alpha- and lipopolysaccharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation.

British journal of pharmacology·1999
Same author

Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells.

Kidney international·1999
Same author

Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells.

Biochemical and biophysical research communications·1999

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Neurology

Context:

  • Hypertensive crisis is a critical medical emergency characterized by a rapid, severe increase in blood pressure.
  • This acute elevation overwhelms the body's natural protective mechanisms, leading to endothelial damage and potential organ dysfunction.
  • Prompt intervention is crucial to prevent irreversible damage to vital organs such as the heart, brain, and kidneys.

Purpose:

  • To outline the immediate therapeutic goals in managing hypertensive crisis.
  • To discuss the efficacy and risks associated with commonly used antihypertensive agents.
  • To highlight the importance of controlled blood pressure reduction in preventing end-organ ischemia.

Summary:

  • Hypertensive crisis necessitates rapid blood pressure reduction, aiming for a 25% decrease within the first hour.

Related Experiment Videos

  • Sodium nitroprusside is a frequently used agent due to its rapid onset and short duration, but carries risks like cyanide toxicity.
  • Alternative treatments have limitations including unpredictable effects, tachycardia, or reduced renal blood flow, underscoring the need for careful agent selection.

    • Impact:

    • Effective management of hypertensive crisis can prevent life-threatening complications and long-term organ damage.
    • Understanding the pharmacodynamics and adverse effects of antihypertensive drugs is vital for optimizing patient outcomes.
    • This information supports clinicians in making informed decisions for the acute management of severely elevated blood pressure.