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Related Experiment Videos

Forced oscillation technique and spirometry in cold air provocation tests

G J Wesseling1, I M Vanderhoven-Augustin, E F Wouters

  • 1Department of Pulmonary Diseases, University Hospital Maastricht, The Netherlands.

Thorax
|March 1, 1993
PubMed
Summary

Cold air provocation in asthma patients causes significant changes in respiratory system impedance, which correlate with decreased forced expiratory volume in one second (FEV1). This impedance analysis offers a valuable tool for evaluating induced bronchoconstriction.

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Area of Science:

  • Respiratory Physiology
  • Pulmonary Medicine
  • Medical Engineering

Background:

  • Respiratory impedance measurements using forced pseudo-random noise oscillation technique assess respiratory system mechanics.
  • Asthma patients experience airway hyperresponsiveness to various stimuli.
  • Cold air is a known provocative agent for inducing bronchoconstriction in asthma.

Purpose of the Study:

  • To analyze impedance changes in asthma patients following a cold air challenge.
  • To correlate these impedance changes with alterations in forced expiratory volume in one second (FEV1).

Main Methods:

  • Sixty asthma patients with a histamine provocative dose (PD20) of <= 8 mumol were studied.
  • Respiratory impedance and spirometry were measured during isocapnic hyperventilation with cold air.

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  • The forced pseudo-random noise oscillation technique was employed for impedance measurements.

    • Main Results:

    • Cold air challenge led to a significant mean decrease in FEV1 by 15.4% of predicted.
    • Oscillatory resistance increased notably, particularly at 8 Hz, and frequency dependence of resistance became more negative.
    • Reactance at 8 Hz decreased, and resonant frequency increased, with significant correlations found between FEV1 changes and impedance parameter alterations.

    Conclusions:

    • Cold air provocation induces measurable changes in respiratory impedance in asthma patients.
    • These impedance changes correlate strongly with FEV1 reduction, indicating ventilatory inhomogeneities.
    • The technique proves valuable for quantitative and qualitative assessment of induced bronchoconstriction in asthma.