Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular-arterial coupling relations in the normal human heart

M R Starling1

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor.

American Heart Journal
|June 1, 1993
PubMed
Summary

The normal human heart operates with optimal left ventricular-arterial coupling, adjusting efficiency based on loading conditions. Increased load improves stroke work but reduces efficiency, while vasodilation decreases stroke work but enhances efficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diastolic dysfunction in the presence of left ventricular systolic dysfunction: implications of beta-adrenergic blocking therapy.

Congestive heart failure (Greenwich, Conn.)·2002
Same author

Transient dobutamine-mediated pulsus alternans.

The Canadian journal of cardiology·2001
Same author

Physiologic assessment of left ventricular systolic and diastolic performance.

Current problems in cardiology·2001
Same author

Relation of systemic sympathetic nervous system activation to echocardiographic left ventricular size and performance and its implications in patients with mitral regurgitation.

The American journal of cardiology·2000
Same author

Echocardiographic markers for mitral valve surgery to preserve left ventricular performance in mitral regurgitation.

American heart journal·2000
Same author

Evaluation of left ventricular ejection fraction as a measure of pump performance in patients with chronic mitral regurgitation.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2000

Area of Science:

  • Cardiology
  • Physiology
  • Biomedical Engineering

Background:

  • Left ventricular-arterial coupling is crucial for cardiac function.
  • Understanding the heart's working point under varying conditions is essential for assessing cardiac efficiency.

Purpose of the Study:

  • To assess left ventricular-arterial coupling in the normal human heart.
  • To determine if the heart operates at optimal output or mechanical efficiency under basal conditions.
  • To investigate the effects of altered loading and inotropic states on cardiac performance.

Main Methods:

  • Cardiac catheterization in 22 patients with atypical chest pain and normal coronary arteriograms.
  • Simultaneous acquisition of radionuclide angiograms and micromanometer left ventricular (LV) pressures.

Related Experiment Videos

  • Hemodynamic measurements under control, methoxamine, nitroprusside, and dobutamine infusion conditions with controlled heart rate.

    • Main Results:

    • The normal heart operated at an Ees/Ea ratio of 1.62, with stroke work of 76 +/- 31 gm-m and mechanical efficiency of 0.65 +/- 0.10.
    • Increased LV load led to an Ees/Ea ratio near 1, increased stroke work, and decreased mechanical efficiency.
    • Vasodilation resulted in an Ees/Ea ratio above 2.0, decreased stroke work, and improved mechanical efficiency.

    Conclusions:

    • The normal human heart's working point is not fixed and varies with loading conditions.
    • Left ventricular-arterial coupling dynamically adjusts to optimize cardiac output and mechanical efficiency.
    • Findings provide insights into the mechanical behavior of the human heart under physiological and pharmacological interventions.