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Effect of Corynebacterium pseudotuberculosis phospholipase D on viability and chemotactic responses of ovine
1Department of Veterinary Science, University of Arizona, Tucson 85721.
American Journal of Veterinary Research
|March 1, 1993
Abstract:
Corynebacterium pseudotuberculosis phospholipase D (PLD) significantly affected viability of ovine neutrophils after 24 hours' exposure. This effect was more marked in cells that ingested PLD emulsified in oil. Treatment of neutrophils with PLD significantly (P < 0.05) reduced the ability of these cells to migrate toward activated sheep serum. The PLD was not chemotactic, but it activated normal sheep serum, producing factors that were chemotactic for neutrophils.