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Related Experiment Videos

Retrograde ejaculation accompanying hyperprolactinemia

H Ishikawa1, S Kaneko, M Ohashi

  • 1Department of Urology, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan.

Archives of Andrology
|May 1, 1993
PubMed
Summary
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Treatment of pituitary tumors with bromocriptine restored antegrade ejaculation in an infertile patient with hyperprolactinemia. This led to natural conception after years of infertility and failed artificial insemination.

Area of Science:

  • Endocrinology
  • Urology
  • Reproductive Medicine

Background:

  • A 38-year-old male patient experienced 10 years of infertility and a 2-year history of ejaculation disorder.
  • Initial diagnosis indicated retrograde ejaculation, and attempts at homologous artificial insemination using retrieved bladder sperm were unsuccessful.

Purpose of the Study:

  • To investigate the cause of infertility and ejaculation disorder in a patient with a history of failed artificial insemination.
  • To evaluate the impact of treating a diagnosed pituitary tumor on reproductive function and fertility.

Main Methods:

  • Hormone tests revealed hyperprolactinemia, hypogonadotropinemia, and hypotestosteronemia.
  • A CT scan identified a pituitary tumor.
  • Treatment involved the administration of 7.5 mg/day of bromocriptine.

Related Experiment Videos

  • Sperm analysis and assessment of ejaculation function were performed before and after treatment.

    • Main Results:

    • Bromocriptine treatment for the pituitary tumor resulted in the recurrence of antegrade ejaculation within 1 month.
    • The patient achieved pregnancy through normal sexual intercourse 5 months after initiating bromocriptine therapy.
    • Hormonal imbalances were corrected, leading to restored reproductive function.

    Conclusions:

    • Pituitary tumors causing hyperprolactinemia can lead to ejaculation disorders and infertility.
    • Bromocriptine is an effective treatment for pituitary tumors, restoring antegrade ejaculation and enabling natural conception in infertile patients.
    • This case highlights the importance of hormonal evaluation and treatment in managing male infertility associated with endocrine disorders.