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Related Experiment Videos

Predictive value of placebo methylphenidate

E Tirosh1, R Elhasid, S C Kamah

  • 1Hannah Khoushy Child Development Center, Bnai Zion Medical Center, Haifa, Israel.

Pediatric Neurology
|March 1, 1993
PubMed
Summary
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Methylphenidate effectively treats attention-deficit disorder in children. A double-blind study confirmed its efficacy using teacher and parent ratings, demonstrating significant improvements in cognitive and motor functions.

Area of Science:

  • Pediatric Neurology
  • Child Psychology
  • Pharmacology

Background:

  • Attention-deficit disorder (ADD) is a common neurodevelopmental disorder in children.
  • Methylphenidate is a commonly prescribed stimulant medication for ADD.
  • Evaluating treatment efficacy requires rigorous study designs.

Purpose of the Study:

  • To assess the effects of methylphenidate in children diagnosed with attention-deficit disorder.
  • To compare placebo versus drug effects using multiple outcome measures.
  • To validate the use of a multimeasure trial for methylphenidate efficacy.

Main Methods:

  • A double-blind, placebo/drug counterbalanced study was conducted.
  • Twenty children aged 7-12 years with ADD participated.

Related Experiment Videos

  • Outcomes were measured using Teacher Rating Scale, Abbreviated Parent Rating Scale, cognitive tests (digits, words, visual sequencing), motor control, and a maze test.

    • Main Results:

    • The placebo-drug difference on the Teacher Rating Scale showed a stronger correlation with outcome measures compared to the baseline-drug difference.
    • Significant improvements were observed across various cognitive and motor assessments.
    • Methylphenidate demonstrated a positive impact on attention and related behaviors.

    Conclusions:

    • The study validates the effectiveness of methylphenidate in managing attention-deficit disorder symptoms in children.
    • A multimeasure, placebo/drug controlled trial is a robust method for evaluating stimulant efficacy.
    • Findings support methylphenidate as a valuable therapeutic option for pediatric ADD.