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[Topical treatment with oxybutynin chloride in neurogenic incontinence]
P López Pereira1, M J Martínez, R Muguerza
1Departamento de Cirugía Pediátrica, Unidad de Urología, Hospital Infantil La Paz, Madrid.
Insights
Intravesical oxybutynin chloride effectively treated neurogenic bladder in children, improving bladder control and increasing capacity. This treatment demonstrated significant urodynamic improvements with no observed systemic side effects.
Area of Science:
- Pediatric Urology
- Pharmacology
- Urodynamics
Context:
- Neurogenic bladder in children often leads to incontinence and requires effective management.
- Previous treatments for neurogenic bladder may cause unacceptable side effects.
- Intravesical administration offers a localized treatment approach.
Purpose:
- To evaluate the efficacy and safety of intravesical oxybutynin chloride in pediatric patients with neurogenic bladder and incontinence.
- To assess the urodynamic changes and clinical outcomes following intravesical oxybutynin chloride treatment.
Summary:
- 12 children with neurogenic bladder and incontinence received intravesical oxybutynin chloride.
- Urodynamic studies showed 100% improvement in hyperreflexia and 88% improvement in low bladder compliance.
- Mean bladder volume increased by 123%, and filling pressure decreased to 24 cm H2O.
- 50% of patients achieved complete dryness, with others showing increased continence periods.
- No systemic side effects were reported during the study.
Impact:
- Intravesical oxybutynin chloride is a safe and effective treatment option for pediatric neurogenic bladder.
- This localized therapy improves bladder function and continence in children.
- The findings support intravesical oxybutynin chloride as an alternative for patients experiencing side effects from other treatments.
Abstract:
Intravesical oxybutynin chloride was administered to 12 children with neurogenic bladder and incontinence who had unacceptable side effects. Urodynamic studies showed hyperreflexia was eliminated or improvement in 100% of them and low compliance was improved (88%), with a mean increase in bladder volume to 123% and a mean decrease of filling pressure to 24 cm H2O. Six patients became completely dry (50%), 4 continent period was increased and 2 did not improve. No systemic effects were observed.