Related Experiment Video
Updated: Aug 9, 2026
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
Published on: September 4, 2017
A comparative endpoint study of lesions induced by MoMuSV-m1, MoMuSV-HT1, MoMuSV-124 and MoMuSV-349
1Department of Veterinary Pathology, Oklahoma State University, College of Veterinary Medicine, Stillwater.
Abstract:
Different MoMuSVs produced predictable clinical, gross, and histologic similarities and differences when inoculated into susceptible hosts intraperitoneally. The neoplasms induced by MoMuSV-124 and MoMuSV-349 were histologically indistinguishable. The distribution of the neoplasms was the most widespread in these two groups. Histologically, the neoplasms induced by MoMuSV-124 and MoMuSV-349 were best described as angioproliferative. The neoplasms induced by MoMuSV-HT1 were most accurately described as fibrosarcomas. Histologically, the neoplasms induced by MoMuSV-m1 had characteristics common to neoplasms induced by MoMuSV-124 and MoMuSV-349, but with a less prominent vascular component. All mice inoculated with these MoMuSVs had moderate to severe thymic atrophy. The degree of thymic atrophy associated with both MoMuSV-124 and MoMuSV-349 was histologically more severe than that associated with MoMuSV-m1 and MoMuSV-HT1. Both MoMuSV-HT1 and MoMuSV-m1 had infiltrates of primitive myeloid cells within the spleen. In the case of MoMuSV-m1, there was an apparent leukaemia with infiltrates of similar cells within the bone marrow. With MoMuSV-HT1, these primitive cells were confined to the spleen. In summary, this study demonstrated that some of the different strains of MoMuSV (with the exception of MoMuSV-124 and MoMuSV-349), induced histologically distinct lesions in BALB/c mice.
Insights
Different Murine Mammary Tumor Virus strains (MoMuSV) induced distinct neoplastic lesions and thymic atrophy in mice. MoMuSV-124 and MoMuSV-349 caused widespread angioproliferative neoplasms, while other strains induced fibrosarcomas or myeloid leukemias.
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Murine Mammary Tumor Virus (MoMuSV) strains are known to induce neoplasms in susceptible hosts.
- Understanding the specific pathological outcomes of different MoMuSV strains is crucial for cancer research.
Purpose of the Study:
- To compare the clinical, gross, and histologic similarities and differences of neoplasms induced by various MoMuSV strains.
- To characterize the distinct pathological lesions and thymic atrophy caused by different MoMuSV isolates in BALB/c mice.
Main Methods:
- Intraperitoneal inoculation of BALB/c mice with different MoMuSV strains (MoMuSV-124, MoMuSV-349, MoMuSV-HT1, MoMuSV-m1).
- Histological examination of induced neoplasms and organs (thymus, spleen, bone marrow).
- Clinical and gross pathological assessment of tumor distribution and severity.
Main Results:
- MoMuSV-124 and MoMuSV-349 induced indistinguishable, widespread angioproliferative neoplasms and severe thymic atrophy.
- MoMuSV-HT1 induced fibrosarcomas, while MoMuSV-m1 showed features of both angioproliferative neoplasms and fibrosarcomas with less vascularity.
- MoMuSV-HT1 and MoMuSV-m1 caused thymic atrophy and splenic infiltrates of primitive myeloid cells; MoMuSV-m1 also showed bone marrow involvement suggestive of leukemia.
Conclusions:
- Different MoMuSV strains induce distinct, predictable histological lesions in BALB/c mice, with MoMuSV-124 and MoMuSV-349 being an exception due to their similarity.
- The study highlights the strain-specific oncogenic potential of MoMuSV, leading to varied neoplastic types and degrees of thymic atrophy.
More Related Videos
13:41Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Published on: January 13, 2023
06:26Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis
Published on: July 28, 2023