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Related Experiment Videos

Fetal ureteric reflux: a follow-up study

J E Scott1

  • 1Department of Surgery, Medical School, University of Newcastle upon Tyne.

British Journal of Urology
|April 1, 1993
PubMed
Summary

This study followed 21 children with antenatal-onset ureteric reflux. Nonoperative management resolved reflux in some, but others required anti-reflux surgery due to worsening conditions.

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Area of Science:

  • Pediatric Urology
  • Neonatal Nephrology
  • Congenital Abnormalities

Background:

  • Ureteric reflux, diagnosed in early infancy and potentially present antenatally, affects renal health.
  • High-grade bilateral reflux presents significant management challenges in neonates.

Purpose of the Study:

  • To describe the outcomes of nonoperative and operative management for antenatal-onset ureteric reflux in children.
  • To evaluate the long-term effects of ureteric reflux on renal parenchyma and urinary tract development.

Main Methods:

  • Retrospective analysis of 21 children diagnosed with ureteric reflux within the first three months of life.
  • Follow-up of 19 children for 2 to 8 years, including radioisotope studies and monitoring for complications.
  • Initial nonoperative management followed by anti-reflux surgery in select cases.

Main Results:

  • Renal parenchymal abnormalities were observed in 45% of non-infected refluxing kidneys.
  • Spontaneous resolution of reflux occurred in 6 children within 2 years.
  • Two children developed secondary pelviureteric junction obstruction; 10 children underwent anti-reflux surgery due to increasing reflux and dilatation.

Conclusions:

  • Nonoperative management can be effective for some cases of early-onset ureteric reflux.
  • Delayed surgical intervention for advanced-grade fetal ureteric reflux may lead to severe complications.
  • Consider surgical treatment for persistent or worsening high-grade reflux after a 2-year observation period.

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