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Recurrent corneal infections in a patient with the acquired immunodeficiency syndrome

R K Hemady1, N Griffin, B Aristimuno

  • 1Department of Ophthalmology, University of Maryland School of Medicine, Baltimore 21201.

Cornea
|May 1, 1993
PubMed

Insights

Recurrent corneal infections in an HIV-positive intravenous drug abuser involved multiple pathogens. Despite complications, one eye retained good vision, highlighting the challenges in managing such cases.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Public Health

Background:

  • Human immunodeficiency virus (HIV) infection can compromise immune function, increasing susceptibility to opportunistic infections.
  • Intravenous drug abuse (IVDA) is a significant risk factor for various infections, including those affecting the cornea.
  • Corneal infections can lead to severe visual impairment or loss, necessitating prompt diagnosis and management.

Observation:

  • A 29-year-old female with HIV experienced recurrent, bilateral corneal infections over 11 months.
  • Multiple pathogens were identified, including Capnocytophaga species, Candida albicans, Staphylococcus aureus, coagulase-negative staphylococcus, and alpha-streptococcus.
  • One eye required evisceration due to perforation and vision loss; the other retained good vision.

Findings:

  • The patient lacked typical predisposing factors for corneal infections.
  • Treatment was severely hampered by poor compliance, ongoing intravenous drug use, and other medical issues.
  • The diverse microbial etiology complicated management and treatment strategies.

Implications:

  • This case underscores the challenges in managing corneal infections in complex patient populations.
  • Effective treatment requires addressing underlying substance abuse and ensuring patient adherence.
  • Ophthalmologists must consider a broad range of pathogens in immunocompromised patients with corneal disease.

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