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Bone scans in neuroblastoma

B M Bhogate1, A M Samuel, P Ramanathan

  • 1Radiation Medicine Centre, B.A.R.C., Parel, Bombay, India.

Indian Journal of Cancer
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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Bone scans using 99m Tc-MDP are valuable for detecting neuroblastoma bone metastases and assessing chemotherapy effectiveness in pediatric patients. This imaging technique helps identify osseous and extraosseous spread, aiding treatment evaluation.

Area of Science:

  • Pediatric Oncology
  • Nuclear Medicine
  • Skeletal Imaging

Background:

  • Neuroblastoma is a common pediatric malignancy.
  • Accurate staging and monitoring are crucial for treatment success.

Purpose of the Study:

  • To evaluate the utility of 99m Tc-MDP bone scintigraphy in neuroblastoma.
  • To assess the ability of bone scans to detect bone metastases and monitor treatment response.

Main Methods:

  • A total of 86 neuroblastoma patients (4 months to 15 years) underwent skeletal surveys using 99m Tc-MDP.
  • Bone imaging was performed three hours post-intravenous administration of the radiotracer.
  • Diagnosis was confirmed via bone marrow examination, FNAC, lymph node biopsy, and histopathology.

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Main Results:

  • 45 out of 86 patients had positive bone scans, revealing 122 osseous and 34 extraosseous metastatic sites.
  • Liver metastases were present in seven patients but did not show MDP concentration.
  • Four out of ten follow-up patients showed a good response, with no demonstrated bony metastases on scintigraphy and X-rays.

Conclusions:

  • 99m Tc-MDP bone scintigraphy is a useful diagnostic tool for neuroblastoma.
  • Bone scans effectively delineate bony metastases and assess chemotherapy efficacy in neuroblastoma patients.