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Renal morphological changes after sinoaortic denervation in dogs

C Orfila1, C Damase-Michel, J C Lepert

  • 1INSERM U 133, Toulouse, France.

Hypertension (Dallas, Tex. : 1979)
|June 1, 1993
PubMed
Summary

Sinoaortic denervation in dogs causes significant kidney damage, including vascular changes and fibrosis, mimicking hypertension. These renal lesions worsen over time, impacting kidney function and structure.

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Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Experimental Pathology

Background:

  • Sinoaortic denervation alters baroreceptor function, impacting cardiovascular regulation.
  • Hypertension is a known risk factor for renal damage.
  • Understanding the renal consequences of sinoaortic denervation is crucial for cardiovascular research.

Purpose of the Study:

  • To investigate the morphological renal lesions following sinoaortic denervation in dogs.
  • To compare renal changes at 1 and 18 months post-denervation with sham-operated controls.
  • To correlate renal pathology with physiological changes like blood pressure and urinary markers.

Main Methods:

  • Sinoaortic denervation was performed on dogs, with sham operations serving as controls.

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  • Renal tissues were examined morphologically at 1 and 18 months post-procedure.
  • Arterial blood pressure, proteinuria, natriuresis, and urinary kallikrein were measured.

    • Main Results:

    • One month post-denervation, dogs showed arteriolar hyalinization, medial thickening, intimal proliferation, and glomerular mesangial expansion.
    • Eighteen months post-denervation, vascular lesions were more severe, with glomerular sclerosis, thickened Bowman's capsule, and prominent tubulointerstitial damage.
    • These morphological changes correlated with increased blood pressure, proteinuria, natriuresis, and decreased urinary kallikrein.

    Conclusions:

    • Chronic sinoaortic denervation induces significant morphological renal lesions in dogs.
    • The observed renal pathology resembles changes seen in experimental and clinical hypertension.
    • Sinoaortic denervation serves as a model for studying hypertension-induced kidney disease.