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Systemic growth hormone does not affect human sleep

W Kern1, R Halder, S al-Reda

  • 1Department of Clinical Neuroendocrinology, University of Leubeck, Germany.

The Journal of Clinical Endocrinology and Metabolism
|June 1, 1993
PubMed
Summary
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This study found that administering growth hormone (GH) or stimulating its release did not affect sleep patterns in healthy men. Systemic GH does not appear to play a physiological role in regulating sleep.

Area of Science:

  • Endocrinology
  • Sleep Medicine
  • Neuroscience

Background:

  • Sleep onset is associated with increased growth hormone (GH) concentrations, suggesting sleep influences GH secretion.
  • However, the reciprocal influence of GH on sleep regulation remains unclear, with inconsistent findings in previous research.

Purpose of the Study:

  • To investigate the effects of exogenous growth hormone (GH) administration and GH secretion stimulated by GH-releasing hormone (GHRH) on sleep architecture in healthy male volunteers.

Main Methods:

  • Three double-blind, within-subject, cross-over experiments were conducted.
  • Methods included intravenous (IV) and intramuscular (IM) administration of varying GH doses, continuous GHRH infusion, and placebo conditions.
  • Sleep patterns were monitored throughout the night in healthy male subjects.

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Main Results:

  • Exogenous GH administration (5 IU IM/IV, 48 IU IV) did not alter total sleep time or time spent in different sleep stages.
  • GHRH infusion increased nocturnal GH secretion but did not impact sleep architecture.
  • Plasma GH and somatomedin-C levels were elevated by GH administration.

Conclusions:

  • Systemic growth hormone (GH) does not exert a significant physiological influence on sleep regulation in healthy humans.
  • Neither direct GH administration nor stimulated GH release affects sleep duration or quality.