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Nephrogenic diabetes insipidus in sibling colts

H C Schott1, W M Bayly, S M Reed

  • 1Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman 99164-6610.

Journal of Veterinary Internal Medicine
|March 1, 1993
PubMed

Insights

Nephrogenic diabetes insipidus, a kidney disorder causing excessive urination and thirst, was diagnosed in two Thoroughbred colts. This condition resulted from their kidney cells being insensitive to vasopressin.

Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Nephrology

Background:

  • Nephrogenic diabetes insipidus (NDI) is a condition characterized by the kidneys' inability to respond to vasopressin.
  • This leads to impaired water reabsorption and excessive urination (polyuria) and thirst (polydipsia).

Observation:

  • Two related Thoroughbred colts presented with severe polyuria and polydipsia, drinking over 80 liters of water daily.
  • Clinical signs suggested a primary renal issue rather than a central cause of diabetes insipidus.

Findings:

  • Diagnostic tests, including water deprivation, hypertonic saline infusion, and vasopressin administration, confirmed the colts' collecting duct cells were insensitive to vasopressin.
  • Elevated plasma vasopressin levels post-water deprivation in one colt ruled out central diabetes insipidus.

Implications:

  • This case highlights NDI as a potential diagnosis in horses exhibiting extreme polyuria and polydipsia.
  • Understanding vasopressin resistance in equine NDI can inform diagnostic approaches and management strategies for affected animals.

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