Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modeling T cell-antigen presenting cell interactions

M A Fishman1, A S Perelson

  • 1Department of Applied Mathematics and Computer Science, Weizmann Institute, Rehovot, Israel.

Journal of Theoretical Biology
|February 7, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy.

Journal of viral hepatitis·2016
Same author

Viral dynamic modelling of Hepatitis C and resistance-associated variants in haemophiliacs.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Selective loss of myelin proteins during autolysis.

Neurochemical research·2013
Same author

Selective decrease of S-100 in discrete anatomical areas of undernourished rat brain.

Neurochemical research·2013
Same author

A perspective on modelling hepatitis C virus infection.

Journal of viral hepatitis·2010
Same author

Modelling hepatitis C virus kinetics during treatment with pegylated interferon alpha-2b: errors in the estimation of viral kinetic parameters.

Journal of viral hepatitis·2008
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
Same journal

Joint likelihood-free inference of the number of selected single nucleotide polymorphisms and their selection coefficients in an evolving population.

Journal of theoretical biology·2026
See all related articles

This study models T-cell activation by antigen-presenting cells (APCs), revealing two outcomes for delayed type hypersensitivity (DTH) reactions: antigen elimination or chronic infection. Dendritic cells are more effective than macrophages in stimulating T cells.

Area of Science:

  • Immunology
  • Computational Biology
  • Mathematical Modeling

Background:

  • Naive T-cell activation by antigen-presenting cells (APCs) is crucial for adaptive immunity.
  • Delayed type hypersensitivity (DTH) is a critical immune response implicated in various diseases.
  • Understanding APC function in T-cell stimulation is key to immune response modulation.

Purpose of the Study:

  • To develop and analyze a mathematical model of T-cell-APC interactions.
  • To investigate the dynamics of delayed type hypersensitivity (DTH) reactions using this model.
  • To compare the efficacy of different APCs (macrophages vs. dendritic cells) in initiating DTH.

Main Methods:

  • Mathematical modeling of T-cell and APC interactions.
  • Analysis of model dynamics to predict immune response outcomes.

Related Experiment Videos

  • Comparative analysis of APC effectiveness based on model simulations.

    • Main Results:

    • The model predicts two distinct DTH response outcomes: complete antigen elimination or a chronic infection state.
    • Both outcomes are consistent with disease pathologies where DTH is the primary defense.
    • Dendritic cells demonstrate superior capacity in stimulating naive T cells compared to macrophages within the model framework.

    Conclusions:

    • The model provides insights into the dichotomous nature of DTH responses.
    • Dendritic cells are predicted to be more effective stimulators of naive T cells than macrophages.
    • This finding supports recent experimental evidence on APC function in initiating immune responses.