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Mechanisms of glycation in atherogenesis
R Pamplona1, M J Bellmunt, M Portero
1Dpt Ciències Mèdiques Bàsiques, Faculty of Medicine, University of Lleida, Spain.
Medical Hypotheses
|March 1, 1993
Abstract:
Non-enzymatic glycation may affect the arterial wall altering its connective tissue and promoting LDL accumulation. Its recognition by specific receptors and growth factor release, as well as possible alteration of DNA, may stimulate smooth muscle cell proliferation. Free radical generation may favour non-enzymatic PUFA degradation and quench NO, which would alter vascular relaxation. All of these aspects may participate in atherogenesis.