[ Ceftriaxone (Rocephin "Roche") in short-term program of perioperational prophylaxis in neurosurgery]

Own experience is presented in the administration of prophylactic antibiotic treatment in clean neurosurgical operations. The clinical material comprised 131 patients subjected to 138 operations. For prophylaxis ceftriaxone (Rocephin "Roche") was given by the so called short term programme in which 2 g of the drug was given intravenously before the operation, and 1 g after 24 hours. The frequency of postoperative infections was 0.7% in the group. The effectiveness is stressed of the short-term programme of prophylactic antibiotic treatment in the prevention of postoperative infections in neurosurgery emphasizing that operations in emergency cases, perioperative steroid therapy, tumours, craniotomy with free bone flap do not reduce the effectiveness of the method.