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Chlamydia-induced reactive arthritis

L H Silveira1, F Gutiérrez, E Scopelitis

  • 1Department of Medicine, Louisiana State University School of Medicine, New Orleans.

Rheumatic Diseases Clinics of North America
|May 1, 1993
PubMed
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Chlamydia trachomatis is a common cause of reactive arthritis. This study found high rates of C. trachomatis infection in patients with Reiter's syndrome and other spondyloarthropathies, supporting antibiotic treatment.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Rheumatology

Background:

  • Chlamydia trachomatis is the most common sexually transmitted infection in the Western World.
  • Reactive arthritis, including Reiter's syndrome, is frequently linked to sexually transmitted infections.
  • Previous studies indicate C. trachomatis is present in 36% to 61% of Reiter's syndrome cases.

Purpose of the Study:

  • To determine the prevalence of C. trachomatis infection in patients with spondyloarthropathies.
  • To assess the role of C. trachomatis in reactive arthritis and related conditions.

Main Methods:

  • Culturing for C. trachomatis in patients with spondyloarthropathies.
  • Serological testing for antibodies against C. trachomatis.
  • Analyzing infection rates in patients with Reiter's syndrome, psoriatic arthritis, and ankylosing spondylitis.

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Main Results:

  • C. trachomatis cultures were positive in 39.4% of Reiter's syndrome patients, 22.2% of psoriatic arthritis patients, and 20% of ankylosing spondylitis patients.
  • Antibodies against C. trachomatis were found in 62.1% of Reiter's syndrome patients, indicating past infection.
  • A significant percentage of patients with spondyloarthropathies showed evidence of C. trachomatis infection.

Conclusions:

  • C. trachomatis is a significant factor in the development of reactive arthritis.
  • Long-term antibiotic therapy is recommended for reactive arthritis patients with C. trachomatis infection.
  • Treatment should extend to sexual partners of infected individuals.