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Candida arthritis

L H Silveira1, M L Cuéllar, G Citera

  • 1Department of Medicine, Louisiana State University School of Medicine, New Orleans.

Rheumatic Diseases Clinics of North America
|May 1, 1993
PubMed
Summary
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Candida species can cause septic arthritis, a rare condition with unknown incidence. Treatment typically involves a combination of medical and surgical approaches, with Amphotericin-B as the preferred antifungal medication.

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Mycology

Background:

  • Septic arthritis can be caused by Candida species, though its incidence is not well-established due to limited reported cases.
  • Two primary clinical presentations of Candida-induced septic arthritis exist: isolated monarthritis from direct inoculation and polyarthritis secondary to disseminated candidiasis.

Purpose of the Study:

  • To review the clinical syndromes and treatment modalities for septic arthritis caused by Candida species.
  • To highlight the challenges in diagnosing and managing this rare fungal infection of the joints.

Main Methods:

  • Literature review of reported cases of Candida septic arthritis.
  • Analysis of clinical presentations, causative Candida species, and treatment outcomes.

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Main Results:

  • Direct intra-articular inoculation (e.g., via injection or surgery) can lead to isolated monarthritis.
  • Hematogenous dissemination of Candida can result in mono- or polyarthritis.
  • Optimal treatment remains undefined, but combined medical and surgical interventions are often employed.

Conclusions:

  • Septic arthritis due to Candida species is an uncommon but significant clinical entity.
  • Amphotericin-B is considered the drug of choice for treating fungal arthritis.
  • A multidisciplinary approach combining antifungal therapy and surgical management is recommended for optimal outcomes.