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The phentolamine test in neurogenic bladder dysfunction

C A Olsson, M B Siroky, R J Krane

    The Journal of Urology
    |April 1, 1977
    PubMed
    Summary
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    Phentolamine testing can predict which patients with neurogenic bladder dysfunction will improve with phenoxybenzamine therapy. A specific nomogram response suggests likely clinical benefit, aiding treatment selection.

    Area of Science:

    • Urology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Neurogenic bladder dysfunction affects urinary flow.
    • Phenoxybenzamine is a potential treatment, but patient selection is key.
    • Predictive tests are needed to guide phenoxybenzamine therapy.

    Purpose of the Study:

    • To evaluate phentolamine's effect on urinary flow rate.
    • To develop a nomogram for interpreting test results.
    • To identify a predictive marker for phenoxybenzamine therapy success.

    Main Methods:

    • Intravenous phentolamine administration in normal and abnormal subjects.
    • Measurement of urinary flow rate.
    • Construction of a nomogram relating mean flow rate to volume voided.

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    Main Results:

    • A nomogram was developed to interpret urinary flow rate changes.
    • In 16 patients with neurogenic bladder dysfunction, a response >0.8 nomogram units predicted improvement.
    • Phentolamine testing demonstrated potential as a predictive tool.

    Conclusions:

    • Phentolamine intravenous testing can predict phenoxybenzamine therapy response in neurogenic bladder.
    • The developed nomogram aids in interpreting test results.
    • This predictive test can improve patient selection for phenoxybenzamine treatment.