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Hypertension in the 1990s: a new disease

C P Kerr1

  • 1Pennsylvania University/Good Samaritan Hospital Family Practice Residency Program, Lebanon.

The Journal of the American Board of Family Practice
|May 1, 1993
PubMed

Insights

Newer hypertension drugs show promise for improving cardiovascular health by positively impacting left ventricular hypertrophy, lipids, and insulin resistance. These advancements may offer benefits not seen in earlier mild-to-moderate hypertension treatment trials.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Major hypertension trials show limited benefits for stroke prevention and no benefit for coronary heart disease in mild-to-moderate cases.
  • Previous treatment strategies for hypertension yielded suboptimal cardiovascular outcomes.

Purpose of the Study:

  • To evaluate the potential cardioprotective effects of newer pharmacologic agents for hypertension.
  • To assess the impact of novel antihypertensive drugs on left ventricular hypertrophy, serum lipids, and insulin resistance.

Main Methods:

  • Conducted a MEDLINE search (1966-1991) using keywords: left ventricular hypertrophy, hypertension, insulin resistance, cholesterol.
  • Reviewed bibliographies of relevant articles and personal files for additional information.

Main Results:

  • Newer agents like alpha-blockers, calcium channel blockers, and ACE inhibitors positively affect left ventricular hypertrophy.
  • These pharmacologic agents demonstrate beneficial effects on serum lipids and insulin levels.

Conclusions:

  • Novel antihypertensive medications offer potential cardioprotective benefits.
  • These drugs may provide cardiovascular advantages in treating mild-to-moderate hypertension, addressing limitations of prior trials.
Abstract

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