Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Deep hypothermia

S Subramanian

    The Johns Hopkins Medical Journal
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Early correction of congenital heart defects using deep hypothermia and circulatory arrest in infants offers comparable or better outcomes than staged repairs. This approach is effective for complex cardiac conditions in young children.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A novel CaO nanocomposite cross linked graphene oxide for Cr(VI) removal and sensing from wastewater.

    Chemosphere·2022
    Same author

    <i>ACTA2</i>-Related Dysgyria: An Under-Recognized Malformation of Cortical Development.

    AJNR. American journal of neuroradiology·2021
    Same author

    Tailoring freshwater diets towards boosted immunity and pancreas disease infection robustness in Atlantic salmon post smolts.

    Fish & shellfish immunology·2021
    Same author

    Adsorption and detoxification of pharmaceutical compounds from wastewater using nanomaterials: A review on mechanism, kinetics, valorization and circular economy.

    Journal of environmental management·2021
    Same author

    Nitrates in the environment: A critical review of their distribution, sensing techniques, ecological effects and remediation.

    Chemosphere·2021
    Same author

    Sustainable removal of Cr(VI) using graphene oxide-zinc oxide nanohybrid: Adsorption kinetics, isotherms and thermodynamics.

    Environmental research·2021
    Same journal

    An approach to the management of dementia syndromes.

    The Johns Hopkins medical journal·1982
    Same journal

    Torsion dystonia.

    The Johns Hopkins medical journal·1982
    Same journal

    The Rieger syndrome: a heritable disorder associated with glaucoma.

    The Johns Hopkins medical journal·1982
    Same journal

    Cerebro-hepato-renal (Zellweger) syndrome and neonatal adrenoleukodystrophy: similarities in phenotype and accumulation of very long chain fatty acids.

    The Johns Hopkins medical journal·1982
    Same journal

    Surgical therapy of complex partial epilepsy.

    The Johns Hopkins medical journal·1982
    Same journal

    Toxic epidermal necrolysis.

    The Johns Hopkins medical journal·1982
    See all related articles

    Area of Science:

    • Pediatric Cardiology
    • Cardiac Surgery
    • Hypothermia in Medicine

    Background:

    • Congenital cardiac defects require timely surgical intervention.
    • Deep hypothermia and cardiocirculatory arrest are established techniques for complex cardiac surgeries.
    • Optimizing surgical strategies for infants with congenital heart disease is crucial.

    Purpose of the Study:

    • To evaluate the efficacy and safety of early primary correction for congenital cardiac defects using deep hypothermia and cardiocirculatory arrest.
    • To compare the outcomes of this approach with staged repair methods in pediatric patients.

    Main Methods:

    • The study involved over 266 pediatric patients, with 67% in their first year of life.
    • Surgical technique included surface cooling to 24°C, hemodilution, cardiopulmonary bypass to 20°C, and cardiocirculatory arrest.

    Related Experiment Videos

  • Rewarming was managed using a pump oxygenator.

    • Main Results:

    • Commonly corrected defects included transposition of the great arteries (43%), ventricular septal defect (16%), and tetralogy of Fallot (16%).
    • The study demonstrated successful correction of various congenital cardiac anomalies.
    • Early primary correction showed a risk profile comparable to or better than staged repair.

    Conclusions:

    • Deep hypothermia and cardiocirculatory arrest facilitate early primary correction of congenital cardiac defects in infants.
    • This approach provides a safe and effective alternative to staged repairs for complex pediatric heart conditions.
    • The findings support the use of early surgical intervention for improved patient outcomes.