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Growth in CHARGE association
Archives of Disease in Childhood
|April 1, 1993
Insights
Children with CHARGE association experience growth deceleration after birth, often remaining small with delayed puberty. Early monitoring and intervention are crucial for managing growth in these individuals.
Area of Science:
- Pediatrics
- Genetics
- Endocrinology
Background:
- CHARGE association is a complex genetic disorder affecting multiple systems.
- Growth patterns in children with CHARGE association require detailed investigation.
Purpose of the Study:
- To analyze growth data in a cohort of children diagnosed with CHARGE association.
- To identify key growth parameters and developmental milestones in affected children.
Main Methods:
- Retrospective analysis of growth data from 44 children (0.5-18 years) with CHARGE association.
- Tracking of weight and length centiles from birth through adolescence.
- Assessment of pubertal development in male participants.
Main Results:
- Children presented with normal birth measurements but showed a significant drop in growth centiles during infancy.
- Participants remained small throughout childhood and adolescence.
- A notable delay in pubertal development was observed in boys.
Conclusions:
- Children with CHARGE association exhibit characteristic growth deceleration and potential pubertal delay.
- Close monitoring of growth is essential for early detection of deviations.
- Timely intervention strategies should be considered to manage growth and development in this population.
Abstract:
Growth data is shown from 44 children (aged 0.5-18 years; 27 boys, 17 girls) with CHARGE association. Children had a normal birth weight and length, but in infancy there was a fall in centiles. Children remained small and there was pubertal delay in boys. Close monitoring of growth with early detection and intervention is recommended.