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Animal models for colon carcinogenesis

S E Pories1, N Ramchurren, I Summerhayes

  • 1Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, Mass.

Archives of Surgery (Chicago, Ill. : 1960)
|June 1, 1993
PubMed
Summary

Understanding colon cancer requires effective animal models. This review covers current and future models, including chemical carcinogen, multiple intestinal neoplasia (MIN), transgenic, and reconstruction models, to advance colon cancer research and therapy.

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Area of Science:

  • Oncology
  • Genetics
  • Animal Models

Background:

  • Genetic alterations in colon polyps and tumors are key to understanding colon carcinogenesis.
  • Observed genetic changes fuel anticipation for new diagnostic tools and interventions for colon cancer.

Purpose of the Study:

  • To review existing and emerging animal models for studying colon cancer.
  • To evaluate the contributions, drawbacks, and potential uses of various models in colon carcinoma research.

Main Methods:

  • Discussion of chemical carcinogen models.
  • Analysis of the multiple intestinal neoplasia (MIN) model.
  • Examination of transgenic animals and reconstruction models.

Main Results:

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  • Each model (chemical carcinogen, MIN, transgenic, reconstruction) offers unique advantages and limitations for studying colon cancer.
  • These models are crucial for testing molecular hypotheses and developing therapeutic strategies.

    • Conclusions:

    • Appropriate animal models are essential for advancing the study of colon cancer.
    • Future research should leverage and refine these models for improved diagnostics and treatments.