Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lessons from lethal albino mice

G Kelsey1, G Schütz

  • 1Division Molecular Biology of Cell I, German Cancer Research Center, Heidelberg.

Current Opinion in Genetics & Development
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ferromagnetic order controlled by the magnetic interface of LaNiO<sub>3</sub>/La<sub>2/3</sub>Ca<sub>1/3</sub>MnO<sub>3</sub> superlattices.

Scientific reports·2023
Same author

Toggle-like current-induced Bloch point dynamics of 3D skyrmion strings in a room temperature nanowire.

Nature communications·2022
Same author

History-dependent domain and skyrmion formation in 2D van der Waals magnet Fe<sub>3</sub>GeTe<sub>2</sub>.

Nature communications·2022
Same author

A distinctive epigenetic ageing profile in human granulosa cells.

Human reproduction (Oxford, England)·2020
Same author

Real-space imaging of confined magnetic skyrmion tubes.

Nature communications·2020
Same author

Anti-Xa levels with low molecular weight heparin calibrator can be used to exclude significant apixaban effect.

Pathology·2019
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

A newly identified liver gene locus regulates gene expression. This enzyme

Area of Science:

  • Genetics and Molecular Biology
  • Biochemistry

Background:

  • Lethal albino deletions in mice have historically suggested a locus regulating gene expression in the liver.
  • The precise function and identity of this locus remained largely uncharacterized.

Purpose of the Study:

  • To identify the specific gene and function of the locus implicated in lethal albino deletions.
  • To re-evaluate the understanding of the lethal albino phenotype based on new findings.

Main Methods:

  • Analysis of mice homozygous for lethal albino deletions.
  • Genetic and biochemical assays to characterize the identified locus.

Main Results:

  • The locus involved in regulating liver gene expression was identified as encoding an enzyme.

Related Experiment Videos

  • This enzyme is active in tyrosine metabolism, a previously unexpected function for this locus.

    • Conclusions:

    • The lethal albino phenotype is linked to a tyrosine metabolism enzyme, necessitating a re-evaluation of its underlying mechanisms.
    • Caution is advised when interpreting simple phenotypes, as they may involve complex genetic and metabolic interactions.