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Lessons from lethal albino mice

G Kelsey1, G Schütz

  • 1Division Molecular Biology of Cell I, German Cancer Research Center, Heidelberg.

Current Opinion in Genetics & Development
|April 1, 1993
PubMed

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...